Can daily oral supplementation with a liquid nutraceutical containing hydrolyzed fish collagen, vitamins, antioxidants, and other active ingredients improve skin texture and elasticity, and protect joint health?
Collagen Peptides, a double-blind, placebo-controlled trial in 120 subjects (Nutrition Research 2018, PMID 30122200) — subjects consuming the test product showed a significant increase in skin elasticity (+40%) compared to placebo. Scope: 120 subjects, over 90 days, and the abstract states no limitations.
Source: Nutrition Research 2018, PMID 30122200 ↗ · Research map · How Magellan grades evidence · evidence confidence: medium
Nutrition Research · 2018 · PMID 30122200 · DOI 10.1016/j.nutres.2018.06.001
A daily supplement with collagen peptides and other nutrients improved skin elasticity and joint health in a 90-day study.
The question
Can daily oral supplementation with a liquid nutraceutical containing hydrolyzed fish collagen, vitamins, antioxidants, and other active ingredients improve skin texture and elasticity, and protect joint health?
What they tested
Daily oral supplementation with a liquid nutraceutical containing hydrolyzed fish collagen, vitamins, antioxidants, and other active ingredients could improve skin texture and elasticity, and have a protective effect on joint health.
How they did it
A double-blind, randomized, placebo-controlled clinical trial was conducted over 90 days. 120 subjects were randomized to consume either the test product or a placebo daily. Skin elasticity was measured, and histological analysis of skin biopsies was performed. Self-perception questionnaires were used to assess skin hydration, elasticity, joint pain, and joint mobility.
What they found
Subjects consuming the test product showed a significant increase in skin elasticity (+40%) compared to placebo. Histological analysis revealed positive changes in skin architecture, including reduced solar elastosis and improved collagen fiber organization. Self-perception questionnaires confirmed subjects' perceptions of more hydrated and elastic skin. The test product also reduced joint pain by -43% and improved joint mobility by +39%.
| Skin Elasticity Increase | 40 | |
|---|---|---|
| Joint Pain Reduction | -43 | |
| Joint Mobility Improvement | 39 |
The test product group experienced a 40% increase in skin elasticity, a 43% reduction in joint pain, and a 39% improvement in joint mobility.
What it means
Oral supplementation with collagen bioactive peptides combined with chondroitin sulphate, glucosamine, L-carnitine, vitamins, and minerals significantly improved clinical parameters related to skin aging and joint health.
Limitations
The abstract does not explicitly state any limitations of the study.
Where the published abstract does not list limitations, we say so rather than inventing them. Read the full paper on PubMed before drawing conclusions.
The paper at a glance
| Title | Daily oral supplementation with collagen peptides combined with vitamins improves skin elasticity and has a beneficial effect on joint and general wellbeing |
|---|---|
| Journal | Nutrition Research |
| Year | 2018 |
| PMID | 30122200 ↗ |
| DOI | 10.1016/j.nutres.2018.06.001 ↗ |
| Topic | Skin, hair & photoaging |
Read the source: PubMed record (authors, abstract, full citation) ↗ · Publisher via doi.org ↗
Where Magellan uses this paper
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Collagen Peptides
Collagen production declines with age, contributing to skin laxity, joint wear and connective-tissue fragility. Randomised trials of oral collagen peptides report measurable improvements in skin elasticity and joint comfort, making collagen a connective-tissue-focused element of a longevity routine.
Molecules & mechanisms in this paper
Each of these is named in the paper’s own words above. Open the monograph for the full mechanism and its other citations.
Cite this page
These citations point at this summary. To cite the original paper with its full author list, use the PubMed record or doi.org.
Magellan Longevity. (2026). Can daily oral supplementation with a liquid nutraceutical containing hydrolyzed fish collagen, vitamins, antioxidants, and other active ingredients improve skin texture and elasticity, and protect joint health? [Plain-English summary of Nutrition Research 2018, PMID 30122200, DOI 10.1016/j.nutres.2018.06.001]. Magellan Longevity. https://magellanlongevity.com/study/collagen_skin.html@misc{magellan_collagen_skin,
title = {Can daily oral supplementation with a liquid nutraceutical containing hydrolyzed fish collagen, vitamins, antioxidants, and other active ingredients improve skin texture and elasticity, and protect joint health?},
author = {{Magellan Longevity}},
year = {2026},
howpublished = {\url{https://magellanlongevity.com/study/collagen_skin.html}},
note = {Plain-English summary of PubMed PMID 30122200; DOI 10.1016/j.nutres.2018.06.001; Nutrition Research 2018. Reviewed by Gabriel Radu, DO},
urldate = {2026-08-11}
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