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Study summary · Cardiovascular & vascular aging

What is the potential role of selenium deficiency and selenium intervention in atherosclerotic heart disease, and how does it interrelate with coenzyme Q10?

In one paragraph

Selenium (J Trace Elem Med Biol 2014, PMID 25511910) — a clinical intervention study in an elderly population using both selenium and coenzyme Q10 showed a reduction in cardiovascular mortality, improved cardiac function by echocardiography, and lower NT-proBNP concentrations in the active treatment group compared to placebo. No numeric effect size is reported for Selenium in the source abstract.

Source: J Trace Elem Med Biol 2014, PMID 25511910 ↗ · Research map · How Magellan grades evidence · evidence confidence: low

J Trace Elem Med Biol · 2014 · PMID 25511910 · DOI 10.1016/j.jtemb.2014.11.006

Plain-English summary written and published by Magellan Longevity · medical review by Gabriel Radu, DO (physiatrist, NPI 1376861765). We summarize what the paper reported — we did not run this study.

The takeaway

Supplementing with selenium and coenzyme Q10 may improve cardiovascular outcomes in elderly individuals, potentially by enhancing antioxidant capacity.

The question

What is the potential role of selenium deficiency and selenium intervention in atherosclerotic heart disease, and how does it interrelate with coenzyme Q10?

What they tested

Selenium deficiency may lead to reduced anti-oxidative capacity, influencing the prognosis of atherosclerotic disease. Combining selenium and coenzyme Q10 may offer a theoretical advantage in intervention due to their anti-oxidative properties.

How they did it

This is a short review discussing the potential role of selenium deficiency and intervention trials in atherosclerotic heart disease. It also presents the interrelationship between selenium and coenzyme Q10 and discusses clinical results from an intervention study using both substances in an elderly population.

What they found

Selenium intake in Europe is often at the lower margin of recommendations, potentially leading to deficient anti-oxidative capacity in conditions like atherosclerotic disease. Increased oxidative stress is demonstrated in ischemic heart disease and heart failure. A clinical intervention study in an elderly population using both selenium and coenzyme Q10 showed a reduction in cardiovascular mortality, improved cardiac function by echocardiography, and lower NT-proBNP concentrations in the active treatment group compared to placebo.

What it means

Selenium deficiency may contribute to atherosclerotic disease due to reduced anti-oxidative capacity. Supplementation with both selenium and coenzyme Q10 in an elderly population demonstrated benefits including reduced cardiovascular mortality, improved cardiac function, and lower myocardial wall tension.

Limitations

The review does not specify the exact details, sample sizes, or statistical significance of the discussed intervention studies. It also does not quantify the observed reductions or improvements.

“reduction in cardiovascular mortality, a better cardiac function according to echocardiography”— from the published abstract, J Trace Elem Med Biol 2014

The paper at a glance

TitleSelenium and coenzyme Q10 interrelationship in cardiovascular diseases
JournalJ Trace Elem Med Biol
Year2014
PMID25511910 ↗
DOI10.1016/j.jtemb.2014.11.006 ↗
TopicCardiovascular & vascular aging

Read the source: PubMed record (authors, abstract, full citation) ↗ · Publisher via doi.org ↗

Molecules & mechanisms in this paper

Each of these is named in the paper’s own words above. Open the monograph for the full mechanism and its other citations.

Coenzyme Q10

Cite this page

These citations point at this summary. To cite the original paper with its full author list, use the PubMed record or doi.org.

APA
Magellan Longevity. (2026). What is the potential role of selenium deficiency and selenium intervention in atherosclerotic heart disease, and how does it interrelate with coenzyme Q10? [Plain-English summary of J Trace Elem Med Biol 2014, PMID 25511910, DOI 10.1016/j.jtemb.2014.11.006]. Magellan Longevity. https://magellanlongevity.com/study/d25511910.html
BibTeX
@misc{magellan_d25511910, title = {What is the potential role of selenium deficiency and selenium intervention in atherosclerotic heart disease, and how does it interrelate with coenzyme Q10?}, author = {{Magellan Longevity}}, year = {2026}, howpublished = {\url{https://magellanlongevity.com/study/d25511910.html}}, note = {Plain-English summary of PubMed PMID 25511910; DOI 10.1016/j.jtemb.2014.11.006; J Trace Elem Med Biol 2014. Reviewed by Gabriel Radu, DO}, urldate = {2026-08-11} }
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How this summary was made. Every section above restates what the published abstract of PMID 25511910 reports — the question, the design, the numbers, the authors’ own conclusion and their stated limitations. We do not add claims the paper did not make, and we keep negative and no-effect findings in. Magellan’s evidence grades are set from research like this and never from affiliate commissions.

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Educational information, not medical advice. This is a plain-English summary of published research; it is not a treatment recommendation and nothing here is intended to diagnose, treat, cure, or prevent any disease. Individual studies can be wrong, and a single paper rarely settles a question. Talk to your physician before acting on any research, especially if you are pregnant, nursing, or taking medication.