What is the impact of cardiorespiratory fitness (CRF) on all-cause and disease-specific mortality?
Cardiorespiratory Fitness, a review (Prog Cardiovasc Dis 2017, PMID 28286137) — cardiorespiratory fitness (CRF) has consistently emerged as a strong, independent predictor of all-cause and disease-specific mortality over the past three decades. No numeric effect size is reported for Cardiorespiratory Fitness in the source abstract.
Source: Prog Cardiovasc Dis 2017, PMID 28286137 ↗ · Research map · How Magellan grades evidence · evidence confidence: low
Prog Cardiovasc Dis · 2017 · PMID 28286137 · DOI 10.1016/j.pcad.2017.03.001
Higher cardiorespiratory fitness is strongly linked to a lower risk of death from all causes and specific diseases.
The question
What is the impact of cardiorespiratory fitness (CRF) on all-cause and disease-specific mortality?
What they tested
The hypothesis is that cardiorespiratory fitness (CRF) is inversely related to all-cause and disease-specific mortality.
How they did it
This is a review article that synthesizes evidence regarding cardiorespiratory fitness (CRF) and mortality, focusing on advances since 2009. It examines studies that used various methods to assess CRF, including directly measured maximal oxygen uptake (VO2max), estimated exercise tests, and non-exercise prediction equations.
What they found
Cardiorespiratory fitness (CRF) has consistently emerged as a strong, independent predictor of all-cause and disease-specific mortality over the past three decades. The inverse relationship between CRF and mortality has been observed despite variations in CRF assessment methods.
What it means
Cardiorespiratory fitness (CRF) is a powerful prognostic indicator for all-cause and disease-specific mortality. The American Heart Association advocates for its routine assessment as a clinical vital sign.
Limitations
The abstract does not explicitly state limitations of the review itself, but it notes that the evidence for CRF's prognostic value exists despite a wide variation of methods used to assess CRF in the studies reviewed.
Where the published abstract does not list limitations, we say so rather than inventing them. Read the full paper on PubMed before drawing conclusions.
The paper at a glance
| Title | Impact of Cardiorespiratory Fitness on All-Cause and Disease-Specific Mortality |
|---|---|
| Journal | Prog Cardiovasc Dis |
| Year | 2017 |
| PMID | 28286137 ↗ |
| DOI | 10.1016/j.pcad.2017.03.001 ↗ |
| Topic | Muscle, strength & physical function |
Read the source: PubMed record (authors, abstract, full citation) ↗ · Publisher via doi.org ↗
Where Magellan uses this paper
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Consumer biometric wearables—smartwatches, wrist-worn bands and finger rings from makers such as Apple…
Consumer biometric wearables—smartwatches, wrist-worn bands and finger rings from makers such as Apple…
Consumer biometric wearables—smartwatches, wrist-worn bands and finger rings from makers such as Apple…
Consumer biometric wearables—smartwatches, wrist-worn bands and finger rings from makers such as Apple…
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Molecules & mechanisms in this paper
Each of these is named in the paper’s own words above. Open the monograph for the full mechanism and its other citations.
Cite this page
These citations point at this summary. To cite the original paper with its full author list, use the PubMed record or doi.org.
Magellan Longevity. (2026). What is the impact of cardiorespiratory fitness (CRF) on all-cause and disease-specific mortality? [Plain-English summary of Prog Cardiovasc Dis 2017, PMID 28286137, DOI 10.1016/j.pcad.2017.03.001]. Magellan Longevity. https://magellanlongevity.com/study/d28286137.html@misc{magellan_d28286137,
title = {What is the impact of cardiorespiratory fitness (CRF) on all-cause and disease-specific mortality?},
author = {{Magellan Longevity}},
year = {2026},
howpublished = {\url{https://magellanlongevity.com/study/d28286137.html}},
note = {Plain-English summary of PubMed PMID 28286137; DOI 10.1016/j.pcad.2017.03.001; Prog Cardiovasc Dis 2017. Reviewed by Gabriel Radu, DO},
urldate = {2026-08-11}
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