What is the overall effect of curcumin supplementation on inflammatory biomarkers?
High-Bioavailability Curcumin, a meta-analysis (Evid Based Complement Alternat Med 2023, PMID 36700039) — a meta-analysis of ten studies with 5,870 participants showed significant decreases in C-reactive protein (CRP) (ES = -0.74), interleukin 6 (IL-6) (ES = -1.07), and tumour necrosis factor (TNF-) levels (ES = -1.92) after curcumin supplementation. The abstract for High-Bioavailability Curcumin states no limitations.
Source: Evid Based Complement Alternat Med 2023, PMID 36700039 ↗ · Research map · How Magellan grades evidence · evidence confidence: medium
Evid Based Complement Alternat Med · 2023 · PMID 36700039 · DOI 10.1155/2023/4875636
Curcumin supplementation significantly reduces key inflammatory biomarkers like CRP, IL-6, and TNF-.
The question
What is the overall effect of curcumin supplementation on inflammatory biomarkers?
What they tested
Curcumin supplementation will reduce inflammatory biomarkers, despite inconsistencies in previous meta-analyses.
How they did it
This umbrella meta-analysis systematically searched PubMed, Scopus, Embase, Web of Science, and Google Scholar until March 20, 2022. It included meta-analysis studies on curcumin's effects on inflammatory biomarkers with corresponding effect sizes and confidence intervals. A random-effects model was used, and the GRADE system evaluated evidence certainty.
What they found
A meta-analysis of ten studies with 5,870 participants showed significant decreases in C-reactive protein (CRP) (ES = -0.74), interleukin 6 (IL-6) (ES = -1.07), and tumour necrosis factor (TNF-) levels (ES = -1.92) after curcumin supplementation. Greater effects on CRP and TNF- were observed in trials with a mean age >45 years and a sample size >300 participants.
| C-reactive protein (CRP) | -0.74 | |
|---|---|---|
| Interleukin 6 (IL-6) | -1.07 | |
| Tumour necrosis factor (TNF-) | -1.92 |
Effect sizes (ES) represent the magnitude of reduction in inflammatory biomarkers following curcumin supplementation.
What it means
Curcumin is a promising agent for reducing inflammation and may serve as an adjunctive therapeutic approach for diseases linked to elevated inflammatory biomarkers.
Limitations
The abstract does not explicitly state limitations of the umbrella meta-analysis itself, beyond acknowledging previous inconsistencies in findings.
Where the published abstract does not list limitations, we say so rather than inventing them. Read the full paper on PubMed before drawing conclusions.
The paper at a glance
| Title | Profiling Inflammatory Biomarkers following Curcumin Supplementation: An Umbrella Meta-Analysis of Randomized Clinical Trials |
|---|---|
| Journal | Evid Based Complement Alternat Med |
| Year | 2023 |
| PMID | 36700039 ↗ |
| DOI | 10.1155/2023/4875636 ↗ |
| Topic | Immunity, inflammation & resilience |
Read the source: PubMed record (authors, abstract, full citation) ↗ · Publisher via doi.org ↗
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High-Bioavailability Curcumin
Meta-analyses of randomized controlled trials generally find that curcumin/turmeric supplementation lowers CRP, IL-6 and TNF-alpha and improves oxidative-stress markers, with symptomatic benefits reported in osteoarthritis and rheumatoid arthritis, modest LDL-cholesterol and triglyceride reductions in cardiometabolic…
Curcumin is the principal curcuminoid and yellow pigment of turmeric (Curcuma longa), a rhizome long…
Research describes the compound or intervention studied. It is not a claim about any specific product.
Molecules & mechanisms in this paper
Each of these is named in the paper’s own words above. Open the monograph for the full mechanism and its other citations.
Cite this page
These citations point at this summary. To cite the original paper with its full author list, use the PubMed record or doi.org.
Magellan Longevity. (2026). What is the overall effect of curcumin supplementation on inflammatory biomarkers? [Plain-English summary of Evid Based Complement Alternat Med 2023, PMID 36700039, DOI 10.1155/2023/4875636]. Magellan Longevity. https://magellanlongevity.com/study/d36700039.html@misc{magellan_d36700039,
title = {What is the overall effect of curcumin supplementation on inflammatory biomarkers?},
author = {{Magellan Longevity}},
year = {2026},
howpublished = {\url{https://magellanlongevity.com/study/d36700039.html}},
note = {Plain-English summary of PubMed PMID 36700039; DOI 10.1155/2023/4875636; Evid Based Complement Alternat Med 2023. Reviewed by Gabriel Radu, DO},
urldate = {2026-08-11}
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