MAGELLAN LONGEVITY
Home › Research › Study library › Potential Modulation of Inflammation by Probiotic and Omega-3…
Study summary · Gut microbiome & digestion

Can a combined probiotic and omega-3 supplement reduce low-grade inflammation in elderly individuals?

In one paragraph

Potential, a randomized trial in 37 participants (Nutrients 2022, PMID 36235651) — no significant difference was observed for hs-CRP between the dual supplement group and placebo. The study did not find a significant reduction in the primary outcome measure, hs-CRP, suggesting the effects on inflammation might be modest or require different markers.

Source: Nutrients 2022, PMID 36235651 ↗ · Research map · How Magellan grades evidence · evidence confidence: low

Nutrients · 2022 · PMID 36235651

Plain-English summary written and published by Magellan Longevity · medical review by Gabriel Radu, DO (physiatrist, NPI 1376861765). We summarize what the paper reported — we did not run this study.

The takeaway

A combined probiotic and omega-3 supplement increased anti-inflammatory markers in elderly individuals, but did not significantly reduce hs-CRP.

The question

Can a combined probiotic and omega-3 supplement reduce low-grade inflammation in elderly individuals?

What they tested

The novel combination of a multi-strain probiotic and omega-3 supplements will reduce low-grade inflammation, as measured by high-sensitivity C-reactive protein (hs-CRP), in elderly participants.

How they did it

This was a proof-of-concept, randomized, placebo-controlled, parallel study involving 76 community-dwelling elderly participants (median age 71.0 years). Participants received either the dual supplement (n=37) or a placebo (n=39) for eight weeks. Hs-CRP, cytokine levels, and intestinal permeability were assessed at baseline and after the intervention.

What they found

No significant difference was observed for hs-CRP between the dual supplement group and placebo. However, supplementation led to significant increases in the anti-inflammatory marker IL-10 and increased levels of valeric acid.

What it means

Probiotic and omega-3 dual supplementation exerts modest effects on inflammation, as evidenced by increased IL-10 and valeric acid, and may have potential as a non-pharmacological treatment for low-grade inflammation in the elderly.

Limitations

The study did not find a significant reduction in the primary outcome measure, hs-CRP, suggesting the effects on inflammation might be modest or require different markers.

“In older adults, multi-strain probiotic supplementation raised the anti-inflammatory cytokine IL-10 and short-chain fatty acids, although hs-CRP did not differ from placebo.”— from the published abstract, Nutrients 2022

The paper at a glance

TitlePotential Modulation of Inflammation by Probiotic and Omega-3 Supplementation in Elderly with Chronic Low-Grade Inflammation: A Randomized, Placebo-Controlled Trial
JournalNutrients
Year2022
PMID36235651 ↗
TopicGut microbiome & digestion
DOINot recorded in our database — use the PubMed record above.

Read the source: PubMed record (authors, abstract, full citation) ↗

Where Magellan uses this paper

This citation sits behind the evidence grade on the pages below. Grades are set from the research and are independent of affiliate commissions.

Probiotics

The strongest human evidence is indication-specific: a Cochrane review of 31 trials (8,672 participants) found probiotics cut the risk of Clostridioides difficile-associated diarrhea during antibiotic use by about 60% (1.5% vs 4.0%), and another Cochrane review found they modestly reduced the incidence and duration…

Probiotic Multi-Strain (50B CFU)

Probiotics are live microorganisms that, when administered in adequate amounts, are intended to confer…

Check price on Amazon ↗

Research describes the compound or intervention studied. It is not a claim about any specific product.

Molecules & mechanisms in this paper

Each of these is named in the paper’s own words above. Open the monograph for the full mechanism and its other citations.

ProbioticsOmega-3 (EPA/DHA)hs-CRP

Cite this page

These citations point at this summary. To cite the original paper with its full author list, use the PubMed record.

APA
Magellan Longevity. (2026). Can a combined probiotic and omega-3 supplement reduce low-grade inflammation in elderly individuals? [Plain-English summary of Nutrients 2022, PMID 36235651]. Magellan Longevity. https://magellanlongevity.com/study/prob_rct.html
BibTeX
@misc{magellan_prob_rct, title = {Can a combined probiotic and omega-3 supplement reduce low-grade inflammation in elderly individuals?}, author = {{Magellan Longevity}}, year = {2026}, howpublished = {\url{https://magellanlongevity.com/study/prob_rct.html}}, note = {Plain-English summary of PubMed PMID 36235651; Nutrients 2022. Reviewed by Gabriel Radu, DO}, urldate = {2026-08-11} }
Permalink
https://magellanlongevity.com/study/prob_rct.html

Related studies in the Magellan library

All 4 Magellan summaries on gut microbiome & digestion →

How this summary was made. Every section above restates what the published abstract of PMID 36235651 reports — the question, the design, the numbers, the authors’ own conclusion and their stated limitations. We do not add claims the paper did not make, and we keep negative and no-effect findings in. Magellan’s evidence grades are set from research like this and never from affiliate commissions.

Prefer the interactive version? Open this summary in the Magellan app → · Browse all 314 study summaries →

Educational information, not medical advice. This is a plain-English summary of published research; it is not a treatment recommendation and nothing here is intended to diagnose, treat, cure, or prevent any disease. Individual studies can be wrong, and a single paper rarely settles a question. Talk to your physician before acting on any research, especially if you are pregnant, nursing, or taking medication.