Can flavonoids be identified that have more potent senolytic activity than previously known combinations, and can these extend health and lifespan?
Fisetin Senolytic Capsules, an animal study (EBioMedicine 2018, PMID 30279143) — intervention with fisetin late in life was sufficient to provide significant health benefits, suggesting its potential for translation into human clinical studies. No numeric effect size is reported for Fisetin Senolytic Capsules in the source abstract.
Source: EBioMedicine 2018, PMID 30279143 ↗ · Research map · How Magellan grades evidence · evidence confidence: low
EBioMedicine · 2018 · PMID 30279143 · DOI 10.1016/j.ebiom.2018.09.015
Fisetin, a natural flavonoid, acts as a potent senolytic in mice and human tissues, reducing age-related pathology and extending lifespan when administered late in life.
The question
Can flavonoids be identified that have more potent senolytic activity than previously known combinations, and can these extend health and lifespan?
What they tested
The researchers hypothesized that certain flavonoid polyphenols would exhibit potent senolytic activity, potentially surpassing existing treatments, and that this activity could translate into improved health and extended lifespan in animal models.
How they did it
A panel of 10 flavonoid polyphenols was screened for senolytic activity using senescent murine and human fibroblasts. The most potent flavonoid, fisetin, was then tested in mice modeling a progeroid syndrome and in aged wild-type mice to assess its effects on senescence markers, age-related histopathology, disease markers, health span, and lifespan. Human adipose tissue explants were also used to evaluate the translatability of the results.
What they found
Fisetin was identified as the most potent senolytic among the 10 flavonoids tested. Acute or intermittent treatment with fisetin reduced senescence markers in multiple tissues in progeroid and old mice, indicating a 'hit-and-run' senolytic mechanism. Fisetin also reduced senescence in specific cell types within murine and human adipose tissue. In wild-type mice, late-life administration of fisetin restored tissue homeostasis, reduced age-related pathology, and extended both median and maximum lifespan.
What it means
The natural product fisetin possesses senotherapeutic activity in mice and human tissues. Intervention with fisetin late in life was sufficient to provide significant health benefits, suggesting its potential for translation into human clinical studies.
Limitations
The study primarily used mouse models and human tissue explants, which may not fully reflect the complexity of human aging and disease. The specific mechanisms of fisetin's cell-type specificity were not fully elucidated.
The paper at a glance
| Title | Fisetin is a senotherapeutic that extends health and lifespan. |
|---|---|
| Journal | EBioMedicine |
| Year | 2018 |
| PMID | 30279143 ↗ |
| DOI | 10.1016/j.ebiom.2018.09.015 ↗ |
| Topic | Senescence, senolytics & the hallmarks of aging |
Read the source: PubMed record (authors, abstract, full citation) ↗ · Publisher via doi.org ↗
Where Magellan uses this paper
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Fisetin Senolytic Capsules
Because senescent cells accumulate with age and contribute to frailty, vascular dysfunction, inflammation, and multiple age-related diseases, selectively clearing them is a leading longevity strategy.
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Several of NOVOS Core's ingredients have genuine, though mostly early-stage, human or animal evidence relevant to aging: trials of GlyNAC (glycine plus N-acetylcysteine) improved oxidative stress, mitochondrial function, strength and walking performance in older adults — though at glycine doses far above what the…
NOVOS Core is a multi-ingredient dietary supplement marketed for longevity that combines about a dozen…
Fisetin is a naturally occurring flavonol (a plant polyphenol) found in strawberries, apples…
Research describes the compound or intervention studied. It is not a claim about any specific product.
Molecules & mechanisms in this paper
Each of these is named in the paper’s own words above. Open the monograph for the full mechanism and its other citations.
Cite this page
These citations point at this summary. To cite the original paper with its full author list, use the PubMed record or doi.org.
Magellan Longevity. (2026). Can flavonoids be identified that have more potent senolytic activity than previously known combinations, and can these extend health and lifespan? [Plain-English summary of EBioMedicine 2018, PMID 30279143, DOI 10.1016/j.ebiom.2018.09.015]. Magellan Longevity. https://magellanlongevity.com/study/s101.html@misc{magellan_s101,
title = {Can flavonoids be identified that have more potent senolytic activity than previously known combinations, and can these extend health and lifespan?},
author = {{Magellan Longevity}},
year = {2026},
howpublished = {\url{https://magellanlongevity.com/study/s101.html}},
note = {Plain-English summary of PubMed PMID 30279143; DOI 10.1016/j.ebiom.2018.09.015; EBioMedicine 2018. Reviewed by Gabriel Radu, DO},
urldate = {2026-08-11}
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