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Study summary · Biological age, epigenetics & aging clocks

Can Rejuvant®, an alpha-ketoglutarate based formulation, reduce biological aging in humans?

Aging · 2021 · PMID 34847066 · DOI 10.18632/aging.203736

Plain-English summary written and published by Magellan Longevity · medical review by Gabriel Radu, DO (physiatrist, NPI 1376861765). We summarize what the paper reported — we did not run this study.

The takeaway

A supplement called Rejuvant® was associated with an average 8-year reduction in biological age in a small study.

The question

Can Rejuvant®, an alpha-ketoglutarate based formulation, reduce biological aging in humans?

What they tested

The researchers hypothesized that Rejuvant® could delay and/or reverse biological aging, extending healthspan and lifespan.

How they did it

This was a retrospective analysis of DNA methylation age in 42 individuals. Participants took Rejuvant® for an average of 7 months. DNA methylation testing was performed at baseline and at the end of the treatment period.

What they found

Individuals showed an average decrease in biological aging of 8 years. A large majority of participants experienced a decrease in their biological age. Rejuvant® appeared to offer additional benefits to chronologically and biologically older individuals.

What it means

Rejuvant® is an intriguing candidate to affect human aging, demonstrating a nearly 8-year reversal in biological age in individuals taking it for 4 to 10 months. Further testing, especially in a placebo-controlled design, is required.

Limitations

The study was a retrospective analysis and lacked a placebo-controlled design, which is noted as a requirement for continued testing.

“individuals showed an average decrease in biological aging of 8 years”— from the published abstract, Aging 2021

The paper at a glance

TitleRejuvant, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging
JournalAging
Year2021
PMID34847066 ↗
DOI10.18632/aging.203736 ↗
TopicBiological age, epigenetics & aging clocks

Read the source: PubMed record (authors, abstract, full citation) ↗ · Publisher via doi.org ↗

Where Magellan uses this paper

This citation sits behind the evidence grade on the pages below. Grades are set from the research and are independent of affiliate commissions.

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Research describes the compound or intervention studied. It is not a claim about any specific product.

Molecules & mechanisms in this paper

Each of these is named in the paper’s own words above. Open the monograph for the full mechanism and its other citations.

DNA methylationEpigenetic clocks

Cite this page

These citations point at this summary. To cite the original paper with its full author list, use the PubMed record or doi.org.

APA
Magellan Longevity. (2026). Can Rejuvant®, an alpha-ketoglutarate based formulation, reduce biological aging in humans? [Plain-English summary of Aging 2021, PMID 34847066, DOI 10.18632/aging.203736]. Magellan Longevity. https://magellanlongevity.com/study/x4.html
BibTeX
@misc{magellan_x4, title = {Can Rejuvant®, an alpha-ketoglutarate based formulation, reduce biological aging in humans?}, author = {{Magellan Longevity}}, year = {2026}, howpublished = {\url{https://magellanlongevity.com/study/x4.html}}, note = {Plain-English summary of PubMed PMID 34847066; DOI 10.18632/aging.203736; Aging 2021. Reviewed by Gabriel Radu, DO}, urldate = {2026-08-11} }
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How this summary was made. Every section above restates what the published abstract of PMID 34847066 reports — the question, the design, the numbers, the authors’ own conclusion and their stated limitations. We do not add claims the paper did not make, and we keep negative and no-effect findings in. Magellan’s evidence grades are set from research like this and never from affiliate commissions.

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Educational information, not medical advice. This is a plain-English summary of published research; it is not a treatment recommendation and nothing here is intended to diagnose, treat, cure, or prevent any disease. Individual studies can be wrong, and a single paper rarely settles a question. Talk to your physician before acting on any research, especially if you are pregnant, nursing, or taking medication.