Does quercetin supplementation affect plasma lipid profiles, blood pressure, and glucose levels in humans?
Quercetin Capsules, a meta-analysis (Nutr Rev 2020, PMID 31940027) — however, subgroup analyses showed significant changes in high-density lipoprotein cholesterol and triglycerides in trials with a parallel design where participants consumed quercetin for 8 weeks or more. No significant changes were observed in overall lipid profiles or glucose concentrations.
Source: Nutr Rev 2020, PMID 31940027 ↗ · Research map · How Magellan grades evidence · evidence confidence: high
Nutr Rev · 2020 · PMID 31940027 · DOI 10.1093/nutrit/nuz071
Quercetin supplementation can lower blood pressure and may improve some lipid markers with longer-term use.
The question
Does quercetin supplementation affect plasma lipid profiles, blood pressure, and glucose levels in humans?
What they tested
The study aimed to summarize evidence regarding the effects of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels in humans.
How they did it
A meta-analysis of randomized controlled trials was conducted. MEDLINE, Embase, and Scopus databases were searched from inception to July 2018. A random-effects model was used for data analysis, expressing continuous variables as weighted mean differences (WMDs) and 95%CIs. Subgroup and sensitivity analyses, as well as publication bias analyses, were also performed.
What they found
Seventeen trials with a total of 896 participants were included. Quercetin significantly lowered systolic blood pressure by -3.09 mmHg and diastolic blood pressure by -2.86 mmHg. No significant changes were observed in overall lipid profiles or glucose concentrations. However, subgroup analyses showed significant changes in high-density lipoprotein cholesterol and triglycerides in trials with a parallel design where participants consumed quercetin for 8 weeks or more.
| Systolic BP Reduction | -3.09 | |
|---|---|---|
| Diastolic BP Reduction | -2.86 |
Quercetin supplementation significantly reduced both systolic and diastolic blood pressure.
What it means
Quercetin intake significantly decreased blood pressure in humans. Additionally, high-density lipoprotein cholesterol and triglycerides levels were significantly changed in participants who consumed quercetin for 8 weeks or more in trials with a parallel design.
Limitations
The abstract does not explicitly state limitations of the meta-analysis itself, but notes that previous clinical trials reported conflicting results.
Where the published abstract does not list limitations, we say so rather than inventing them. Read the full paper on PubMed before drawing conclusions.
The paper at a glance
| Title | Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels: a meta-analysis |
|---|---|
| Journal | Nutr Rev |
| Year | 2020 |
| PMID | 31940027 ↗ |
| DOI | 10.1093/nutrit/nuz071 ↗ |
| Topic | Cardiovascular & vascular aging |
Read the source: PubMed record (authors, abstract, full citation) ↗ · Publisher via doi.org ↗
Where Magellan uses this paper
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Quercetin Capsules
Meta-analyses of randomized trials indicate quercetin produces a small blood-pressure reduction—on the order of 2–3 mmHg—most apparent at doses of at least 500 mg/day and in people with hypertension rather than normal blood pressure;
Quercetin is a flavonol, a plant polyphenol found abundantly in onions, apples, berries, capers, and…
Research describes the compound or intervention studied. It is not a claim about any specific product.
Molecules & mechanisms in this paper
Each of these is named in the paper’s own words above. Open the monograph for the full mechanism and its other citations.
Cite this page
These citations point at this summary. To cite the original paper with its full author list, use the PubMed record or doi.org.
Magellan Longevity. (2026). Does quercetin supplementation affect plasma lipid profiles, blood pressure, and glucose levels in humans? [Plain-English summary of Nutr Rev 2020, PMID 31940027, DOI 10.1093/nutrit/nuz071]. Magellan Longevity. https://magellanlongevity.com/study/d31940027.html@misc{magellan_d31940027,
title = {Does quercetin supplementation affect plasma lipid profiles, blood pressure, and glucose levels in humans?},
author = {{Magellan Longevity}},
year = {2026},
howpublished = {\url{https://magellanlongevity.com/study/d31940027.html}},
note = {Plain-English summary of PubMed PMID 31940027; DOI 10.1093/nutrit/nuz071; Nutr Rev 2020. Reviewed by Gabriel Radu, DO},
urldate = {2026-08-11}
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