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Study summary · Cardiovascular & vascular aging

Does quercetin supplementation affect blood pressure?

J Am Heart Assoc · 2016 · PMID 27405810 · DOI 10.1161/JAHA.115.002713

Plain-English summary written and published by Magellan Longevity · medical review by Gabriel Radu, DO (physiatrist, NPI 1376861765). We summarize what the paper reported — we did not run this study.

The takeaway

Quercetin supplementation, especially at doses of 500 mg/day or more, may help reduce both systolic and diastolic blood pressure.

The question

Does quercetin supplementation affect blood pressure?

What they tested

The evidence regarding quercetin's effects on blood pressure has been inconclusive, so this meta-analysis aims to assess its impact.

How they did it

A systematic review and meta-analysis of placebo-controlled randomized controlled trials were conducted. Databases including PUBMED, Cochrane Library, Scopus, and EMBASE were searched up to January 31, 2015. Meta-analysis used either fixed-effects or random-effect models, with effect size expressed as weighted mean difference (WMD) and 95% CI.

What they found

The meta-analysis included 7 trials with 9 treatment arms and 587 patients. Quercetin supplementation significantly reduced systolic BP (WMD: -3.04 mm Hg) and diastolic BP (WMD: -2.63 mm Hg). For doses ">="500 mg/day, significant reductions were observed in systolic BP (WMD: -4.45 mm Hg) and diastolic BP (WMD: -2.98 mm Hg). Doses "<"500 mg/day did not show a significant effect on either systolic BP (WMD: -1.59 mm Hg) or diastolic BP (WMD: -0.24 mm Hg), though indirect comparison tests between doses were not significant.

Effect of Quercetin on Blood Pressure
Values shown: WMD (mm Hg)
Overall Systolic BP Reduction-3.04
Overall Diastolic BP Reduction-2.63
Systolic BP Reduction (≥500 mg/day)-4.45
Diastolic BP Reduction (≥500 mg/day)-2.98
Systolic BP Reduction (<500 mg/day)-1.59
Diastolic BP Reduction (<500 mg/day)-0.24

Weighted mean difference (WMD) in blood pressure reduction (mm Hg) following quercetin supplementation, overall and by dose category.

What it means

Quercetin supplementation has a statistically significant effect in reducing blood pressure, with this effect possibly limited to or greater with dosages of ">"500 mg/day.

Limitations

The abstract does not explicitly state limitations of the study, but it does call for further studies to investigate clinical relevance and potential application as an add-on therapy.

Where the published abstract does not list limitations, we say so rather than inventing them. Read the full paper on PubMed before drawing conclusions.

“significant reductions both in systolic BP and diastolic BP following supplementation with quercetin”— from the published abstract, J Am Heart Assoc 2016

The paper at a glance

TitleEffects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
JournalJ Am Heart Assoc
Year2016
PMID27405810 ↗
DOI10.1161/JAHA.115.002713 ↗
TopicCardiovascular & vascular aging

Read the source: PubMed record (authors, abstract, full citation) ↗ · Publisher via doi.org ↗

Where Magellan uses this paper

This citation sits behind the evidence grade on the pages below. Grades are set from the research and are independent of affiliate commissions.

Quercetin Capsules

Meta-analyses of randomized trials indicate quercetin produces a small blood-pressure reduction—on the order of 2–3 mmHg—most apparent at doses of at least 500 mg/day and in people with hypertension rather than normal blood pressure;

Quercetin Capsules

Quercetin is a flavonol, a plant polyphenol found abundantly in onions, apples, berries, capers, and…

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Research describes the compound or intervention studied. It is not a claim about any specific product.

Molecules & mechanisms in this paper

Each of these is named in the paper’s own words above. Open the monograph for the full mechanism and its other citations.

Blood pressureQuercetin

Cite this page

These citations point at this summary. To cite the original paper with its full author list, use the PubMed record or doi.org.

APA
Magellan Longevity. (2026). Does quercetin supplementation affect blood pressure? [Plain-English summary of J Am Heart Assoc 2016, PMID 27405810, DOI 10.1161/JAHA.115.002713]. Magellan Longevity. https://magellanlongevity.com/study/d27405810.html
BibTeX
@misc{magellan_d27405810, title = {Does quercetin supplementation affect blood pressure?}, author = {{Magellan Longevity}}, year = {2026}, howpublished = {\url{https://magellanlongevity.com/study/d27405810.html}}, note = {Plain-English summary of PubMed PMID 27405810; DOI 10.1161/JAHA.115.002713; J Am Heart Assoc 2016. Reviewed by Gabriel Radu, DO}, urldate = {2026-08-11} }
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How this summary was made. Every section above restates what the published abstract of PMID 27405810 reports — the question, the design, the numbers, the authors’ own conclusion and their stated limitations. We do not add claims the paper did not make, and we keep negative and no-effect findings in. Magellan’s evidence grades are set from research like this and never from affiliate commissions.

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Educational information, not medical advice. This is a plain-English summary of published research; it is not a treatment recommendation and nothing here is intended to diagnose, treat, cure, or prevent any disease. Individual studies can be wrong, and a single paper rarely settles a question. Talk to your physician before acting on any research, especially if you are pregnant, nursing, or taking medication.