What is the effectiveness of olive leaf extract on cardiometabolic profiles among adults with prehypertension and hypertension?
Olive Leaf Extract, a systematic review and meta-analysis in 325 patients (PeerJ 2021, PMID 33868820) — a daily dose of 500 mg of olive leaf extract significantly reduced systolic BP by -5.78 mmHg over at least 8 weeks compared to placebo, but had no significant effect on diastolic BP. The main limitation is the small number of participants across the included trials, which may affect the robustness of the conclusions.
Source: PeerJ 2021, PMID 33868820 ↗ · Research map · How Magellan grades evidence · evidence confidence: high
PeerJ · 2021 · PMID 33868820 · DOI 10.7717/peerj.11173
Olive leaf extract may help reduce systolic blood pressure, LDL, and inflammatory markers, but more research is needed to confirm its overall cardiometabolic benefits.
The question
What is the effectiveness of olive leaf extract on cardiometabolic profiles among adults with prehypertension and hypertension?
What they tested
The study hypothesized that olive leaf extract would improve cardiometabolic profiles in prehypertensive and hypertensive individuals.
How they did it
This systematic review and meta-analysis included five randomized clinical trials with 325 patients aged 18-80 years. Data from Cochrane, Medline, Embase, and trial registries were analyzed using random effects models to estimate mean differences and 95% confidence intervals for continuous outcomes. Primary outcomes were changes in systolic and diastolic blood pressure, while secondary outcomes included lipid profile, glucose metabolism, inflammatory markers, and kidney/liver functions.
What they found
A daily dose of 500 mg of olive leaf extract significantly reduced systolic BP by -5.78 mmHg over at least 8 weeks compared to placebo, but had no significant effect on diastolic BP. A 1,000 mg daily dose of olive leaf extract versus captopril reduced LDL by -6.00 mg/dl. The 500 mg daily dose also reduced inflammatory markers IL-6 by -6.83 ng/L, IL-8 by -8.24 ng/L, and TNF-alpha by -7.40 ng/L compared to placebo. No significant changes in systolic or diastolic BP were found for 1,000 mg/day of a combined formulation or 1,000 mg/day of olive leaf extract alone versus placebo.
| Systolic BP (500mg OLE vs Placebo) | -5.78 | |
|---|---|---|
| LDL (1000mg OLE vs Captopril) | -6 | |
| IL-6 (500mg OLE vs Placebo) | -6.83 | |
| IL-8 (500mg OLE vs Placebo) | -8.24 | |
| TNF-alpha (500mg OLE vs Placebo) | -7.4 |
Mean differences in mmHg for systolic BP and mg/dl or ng/L for other markers, showing reductions with olive leaf extract.
What it means
Olive leaf extract may reduce systolic blood pressure, LDL cholesterol, and inflammatory biomarkers. However, the limited number of participants in the included trials prevents a robust conclusion regarding its overall effects on cardiometabolic profiles.
Limitations
The main limitation is the small number of participants across the included trials, which may affect the robustness of the conclusions.
The paper at a glance
| Title | Olive leaf extract effect on cardiometabolic profile among adults with prehypertension and hypertension: a meta-analysis |
|---|---|
| Journal | PeerJ |
| Year | 2021 |
| PMID | 33868820 ↗ |
| DOI | 10.7717/peerj.11173 ↗ |
| Topic | Cardiovascular & vascular aging |
Read the source: PubMed record (authors, abstract, full citation) ↗ · Publisher via doi.org ↗
Where Magellan uses this paper
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Olive Leaf Extract (Oleuropein)
In human trials, standardized olive leaf extract has most consistently produced modest reductions in systolic and diastolic blood pressure in people with prehypertension or hypertension, and several trials and meta-analyses also report small decreases in total and LDL cholesterol and triglycerides.
Olive leaf extract (OLE) is a botanical preparation derived from the leaves of the olive tree (Olea…
Research describes the compound or intervention studied. It is not a claim about any specific product.
Molecules & mechanisms in this paper
Each of these is named in the paper’s own words above. Open the monograph for the full mechanism and its other citations.
Cite this page
These citations point at this summary. To cite the original paper with its full author list, use the PubMed record or doi.org.
Magellan Longevity. (2026). What is the effectiveness of olive leaf extract on cardiometabolic profiles among adults with prehypertension and hypertension? [Plain-English summary of PeerJ 2021, PMID 33868820, DOI 10.7717/peerj.11173]. Magellan Longevity. https://magellanlongevity.com/study/d33868820.html@misc{magellan_d33868820,
title = {What is the effectiveness of olive leaf extract on cardiometabolic profiles among adults with prehypertension and hypertension?},
author = {{Magellan Longevity}},
year = {2026},
howpublished = {\url{https://magellanlongevity.com/study/d33868820.html}},
note = {Plain-English summary of PubMed PMID 33868820; DOI 10.7717/peerj.11173; PeerJ 2021. Reviewed by Gabriel Radu, DO},
urldate = {2026-08-11}
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