Is long-term systolic blood pressure variability (SBPV) associated with cardiovascular (CV) outcomes, even after adjusting for mean blood pressure?
Long-term systolic blood pressure variability, a systematic review and meta-analysis in 9,944,254 subjects (Curr Probl Cardiol 2023, PMID 38103812) — long-term SBPV was associated with an increased risk of all-cause mortality (HR 1.21), CV mortality (HR 1.10), major adverse cardiovascular events (MACE) (HR 1.10), cerebrovascular stroke (HR 1.22), and myocardial infarction (HR 1.13). Scope: 9,944,254 subjects, and the abstract states no limitations.
Source: Curr Probl Cardiol 2023, PMID 38103812 ↗ · Research map · How Magellan grades evidence · evidence confidence: medium
Curr Probl Cardiol · 2023 · PMID 38103812 · DOI 10.1016/j.cpcardiol.2023.102343
Higher long-term systolic blood pressure variability is associated with increased risks of death and cardiovascular events, particularly stroke.
The question
Is long-term systolic blood pressure variability (SBPV) associated with cardiovascular (CV) outcomes, even after adjusting for mean blood pressure?
What they tested
The study aims to evaluate the associations between mean blood pressure adjusted long-term SBPV and CV outcomes, suggesting a potential association.
How they did it
A systematic review and meta-analysis was conducted by searching PubMed, Scopus, and Science Direct on January 4, 2023. The analysis included 43 studies with a total of 9,944,254 subjects.
What they found
Long-term SBPV was associated with an increased risk of all-cause mortality (HR 1.21), CV mortality (HR 1.10), major adverse cardiovascular events (MACE) (HR 1.10), cerebrovascular stroke (HR 1.22), and myocardial infarction (HR 1.13). European populations showed a generally higher risk compared to other continents.
| All-cause mortality | 1.21 | |
|---|---|---|
| Cerebrovascular stroke | 1.22 | |
| Myocardial infarction | 1.13 | |
| CV mortality | 1.1 | |
| MACE | 1.1 |
Hazard ratios indicate the increased risk of various outcomes associated with long-term systolic blood pressure variability.
What it means
Long-term SBPV is associated with all-cause mortality, CV mortality, MACE, myocardial infarction, and stroke. Poor outcomes linked to long-term SBPV appear to be more driven by cerebrovascular events than coronary events.
Limitations
The abstract does not explicitly state limitations of the meta-analysis itself, but notes the questionability of the association after adjusting for mean BP, which the study aimed to address.
Where the published abstract does not list limitations, we say so rather than inventing them. Read the full paper on PubMed before drawing conclusions.
The paper at a glance
| Title | Long-term systolic blood pressure variability is associated with mortality and cardiovascular events: a meta-analysis |
|---|---|
| Journal | Curr Probl Cardiol |
| Year | 2023 |
| PMID | 38103812 ↗ |
| DOI | 10.1016/j.cpcardiol.2023.102343 ↗ |
| Topic | Cardiovascular & vascular aging |
Read the source: PubMed record (authors, abstract, full citation) ↗ · Publisher via doi.org ↗
Where Magellan uses this paper
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Molecules & mechanisms in this paper
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Cite this page
These citations point at this summary. To cite the original paper with its full author list, use the PubMed record or doi.org.
Magellan Longevity. (2026). Is long-term systolic blood pressure variability (SBPV) associated with cardiovascular (CV) outcomes, even after adjusting for mean blood pressure? [Plain-English summary of Curr Probl Cardiol 2023, PMID 38103812, DOI 10.1016/j.cpcardiol.2023.102343]. Magellan Longevity. https://magellanlongevity.com/study/d38103812.html@misc{magellan_d38103812,
title = {Is long-term systolic blood pressure variability (SBPV) associated with cardiovascular (CV) outcomes, even after adjusting for mean blood pressure?},
author = {{Magellan Longevity}},
year = {2026},
howpublished = {\url{https://magellanlongevity.com/study/d38103812.html}},
note = {Plain-English summary of PubMed PMID 38103812; DOI 10.1016/j.cpcardiol.2023.102343; Curr Probl Cardiol 2023. Reviewed by Gabriel Radu, DO},
urldate = {2026-08-11}
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