What are the safety and antiaging effects of nicotinamide mononucleotide (NMN) in human clinical trials?
Nicotinamide Mononucleotide, a clinical trial (Advances in Nutrition 2023, PMID 37619764) — while NMN shows promise in animal and cell studies for antiaging, human clinical trial data is still largely pending. No numeric effect size is reported for Nicotinamide Mononucleotide in the source abstract.
Source: Advances in Nutrition 2023, PMID 37619764 ↗ · Research map · How Magellan grades evidence · evidence confidence: low
Advances in Nutrition · 2023 · PMID 37619764 · DOI 10.1016/j.advnut.2023.08.008
While NMN shows promise in animal and cell studies for antiaging, human clinical trial data is still largely pending.
The question
What are the safety and antiaging effects of nicotinamide mononucleotide (NMN) in human clinical trials?
What they tested
NMN supplementation, by increasing NAD concentration, could mitigate aging-related disorders such as oxidative stress, DNA damage, neurodegeneration, and inflammatory responses in humans, similar to findings in cell and animal models.
How they did it
This is a review article summarizing the current progress of human clinical trials investigating NMN supplementation and its effects, along with an overview of NMN/NAD biology.
What they found
The review notes that a dozen human clinical trials with NMN supplementation are currently underway. It highlights that in vitro/in vivo studies have demonstrated NMN supplementation increases NAD concentration and could mitigate aging-related disorders.
What it means
The review aims to clarify the potential effects of NMN supplementation and suggest future study directions, acknowledging that most existing evidence comes from cell or animal models, with human trial results still emerging.
Limitations
Most studies evaluating the effects of NMN have been conducted in cell or animal models, leading to a concern regarding the safety and physiological effects of NMN supplementation in the human population.
The paper at a glance
| Title | The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update. |
|---|---|
| Journal | Advances in Nutrition |
| Year | 2023 |
| PMID | 37619764 ↗ |
| DOI | 10.1016/j.advnut.2023.08.008 ↗ |
| Topic | NAD⁺, sirtuins & cellular energy |
Read the source: PubMed record (authors, abstract, full citation) ↗ · Publisher via doi.org ↗
Where Magellan uses this paper
This citation sits behind the evidence grade on the pages below. Grades are set from the research and are independent of affiliate commissions.
Nicotinamide Mononucleotide (NMN)
In randomized controlled trials, NMN reliably increases blood NAD+ levels and has generally been well tolerated at oral doses up to roughly 900-1250 mg/day, with some trials reporting modest improvements in skeletal-muscle insulin sensitivity, walking speed, aerobic capacity, sleep quality, and diastolic blood…
Intracellular NAD⁺ & Longevity Marker Testing
Because NAD⁺ declines with age and powers sirtuins and DNA repair, measuring intracellular NAD⁺ lets users see their baseline and confirm whether precursors such as NMN are actually raising it — closing the loop between intervention and outcome.
Nicotinamide mononucleotide (NMN) is a naturally occurring nucleotide and a direct biosynthetic…
Nicotinamide mononucleotide (NMN) is a naturally occurring nucleotide and a direct biosynthetic…
Nicotinamide mononucleotide (NMN) is a naturally occurring nucleotide and a direct biosynthetic…
Nicotinamide mononucleotide (NMN) is a naturally occurring nucleotide and a direct biosynthetic…
Nicotinamide mononucleotide (NMN) is a naturally occurring nucleotide and a direct biosynthetic…
Nicotinamide mononucleotide (NMN) is a naturally occurring nucleotide and a direct biosynthetic…
Research describes the compound or intervention studied. It is not a claim about any specific product.
Molecules & mechanisms in this paper
Each of these is named in the paper’s own words above. Open the monograph for the full mechanism and its other citations.
Cite this page
These citations point at this summary. To cite the original paper with its full author list, use the PubMed record or doi.org.
Magellan Longevity. (2026). What are the safety and antiaging effects of nicotinamide mononucleotide (NMN) in human clinical trials? [Plain-English summary of Advances in Nutrition 2023, PMID 37619764, DOI 10.1016/j.advnut.2023.08.008]. Magellan Longevity. https://magellanlongevity.com/study/nmn_update.html@misc{magellan_nmn_update,
title = {What are the safety and antiaging effects of nicotinamide mononucleotide (NMN) in human clinical trials?},
author = {{Magellan Longevity}},
year = {2026},
howpublished = {\url{https://magellanlongevity.com/study/nmn_update.html}},
note = {Plain-English summary of PubMed PMID 37619764; DOI 10.1016/j.advnut.2023.08.008; Advances in Nutrition 2023. Reviewed by Gabriel Radu, DO},
urldate = {2026-08-11}
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- The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy…GeroScience · 2022 · PMID 36482258
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