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Study summary · General aging biology & healthspan

Is serum uric acid (SUA) level associated with all-cause and cardiovascular disease (CVD) mortality in individuals with diabetes?

Diabetes Care · 2023 · PMID 36490263 · DOI 10.2337/dc22-1339

Plain-English summary written and published by Magellan Longevity · medical review by Gabriel Radu, DO (physiatrist, NPI 1376861765). We summarize what the paper reported — we did not run this study.

The takeaway

Higher serum uric acid levels are linked to increased mortality risk in people with diabetes.

The question

Is serum uric acid (SUA) level associated with all-cause and cardiovascular disease (CVD) mortality in individuals with diabetes?

What they tested

The study investigates an association between serum uric acid levels and mortality, implying a potential link.

How they did it

This prospective cohort study analyzed data from 7,101 patients with diabetes from the U.S. National Health and Nutritional Examination Survey (NHANES) 1999-2018. Mortality data were linked to national death records through December 31, 2019. Weighted Cox proportional hazards regression models were used to calculate hazard ratios (HRs) for all-cause and CVD mortality. A meta-analysis of 13 additional cohort studies was also performed.

What they found

Among NHANES participants, the weighted mean SUA level was 5.7 mg/dL. During 57,926 person-years of follow-up, there were 1,900 deaths, with 674 attributed to CVD. Patients in the highest SUA quintile had an HR of 1.28 for all-cause mortality and 1.41 for CVD mortality compared to those in the lowest SUA quintile. The meta-analysis of 13 cohort studies showed pooled HRs of 1.08 for all-cause mortality and 1.05 for CVD mortality per 1 mg/dL increment of SUA.

Mortality Risk by Serum Uric Acid Quintile in Diabetes Patients

Values shown: Hazard Ratio

All-cause mortality (highest vs. lowest quintile)		1.28
CVD mortality (highest vs. lowest quintile)		1.41

Hazard ratios for all-cause and CVD mortality when comparing the highest serum uric acid quintile to the lowest quintile in diabetes patients.

What it means

Higher serum uric acid levels are associated with increased risks of both all-cause and cardiovascular disease mortality in individuals with diabetes.

Limitations

The study design is observational, which means it can identify associations but not prove causation. The abstract does not explicitly state other limitations.

Where the published abstract does not list limitations, we say so rather than inventing them. Read the full paper on PubMed before drawing conclusions.

“higher serum uric acid levels were associated with increased risks of all-cause and cardiovascular mortality”— from the published abstract, Diabetes Care 2023

The paper at a glance

Magellan’s evidence label	Serum uric acid (our label for this citation — see PubMed for the paper’s own title and authors)
Journal	Diabetes Care
Year	2023
PMID	36490263 ↗
DOI	10.2337/dc22-1339 ↗
Topic	General aging biology & healthspan

Read the source: PubMed record (authors, abstract, full citation) ↗ · Publisher via doi.org ↗

Cite this page

These citations point at this summary. To cite the original paper with its full author list, use the PubMed record or doi.org.

APA

Magellan Longevity. (2026). Is serum uric acid (SUA) level associated with all-cause and cardiovascular disease (CVD) mortality in individuals with diabetes? [Plain-English summary of Diabetes Care 2023, PMID 36490263, DOI 10.2337/dc22-1339]. Magellan Longevity. https://magellanlongevity.com/study/s151.html

BibTeX

@misc{magellan_s151,
  title        = {Is serum uric acid (SUA) level associated with all-cause and cardiovascular disease (CVD) mortality in individuals with diabetes?},
  author       = {{Magellan Longevity}},
  year         = {2026},
  howpublished = {\url{https://magellanlongevity.com/study/s151.html}},
  note         = {Plain-English summary of PubMed PMID 36490263; DOI 10.2337/dc22-1339; Diabetes Care 2023. Reviewed by Gabriel Radu, DO},
  urldate      = {2026-08-11}
}

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How this summary was made. Every section above restates what the published abstract of PMID 36490263 reports — the question, the design, the numbers, the authors’ own conclusion and their stated limitations. We do not add claims the paper did not make, and we keep negative and no-effect findings in. Magellan’s evidence grades are set from research like this and never from affiliate commissions.

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Educational information, not medical advice. This is a plain-English summary of published research; it is not a treatment recommendation and nothing here is intended to diagnose, treat, cure, or prevent any disease. Individual studies can be wrong, and a single paper rarely settles a question. Talk to your physician before acting on any research, especially if you are pregnant, nursing, or taking medication.