Can resveratrol supplementation improve bone health in postmenopausal women?
Trans-Resveratrol, a randomized, double-blind, placebo-controlled trial (J Bone Miner Res 2020, PMID 32564438) — after 12 months, resveratrol supplementation increased bone density in the lumbar spine by +0.016 g/cm and in the neck of the femur by +0.005 g/cm compared to placebo. The abstract for Trans-Resveratrol states no limitations.
Source: J Bone Miner Res 2020, PMID 32564438 ↗ · Research map · How Magellan grades evidence · evidence confidence: medium
J Bone Miner Res · 2020 · PMID 32564438 · DOI 10.1002/jbmr.4115
Daily resveratrol supplementation may help slow bone loss in the spine and hip of postmenopausal women.
The question
Can resveratrol supplementation improve bone health in postmenopausal women?
What they tested
Resveratrol supplementation will improve bone health in postmenopausal women, possibly through circulatory benefits in bone tissue, given its phytoestrogen properties and bone-protective effects observed in rodent models.
How they did it
The RESHAW trial was a 24-month randomized, double-blind, placebo-controlled, two-period crossover intervention. Postmenopausal women received 75 mg of resveratrol twice daily or a placebo. The study evaluated effects on cognition, cerebrovascular function, bone health, cardiometabolic markers, and well-being.
What they found
After 12 months, resveratrol supplementation increased bone density in the lumbar spine by +0.016 g/cm and in the neck of the femur by +0.005 g/cm compared to placebo. This was accompanied by a 7.24% reduction in C-terminal telopeptide type-1 collagen levels. The femoral neck T-score improved by +0.070, reducing the 10-year probability of major and hip fracture risk. The bone-protective benefit was greater in women with poor bone health biomarker status and in those who supplemented with vitamin D plus calcium.
| Lumbar Spine | 0.016 | |
|---|---|---|
| Femoral Neck | 0.005 |
Resveratrol supplementation led to an increase in bone mineral density in the lumbar spine and femoral neck.
What it means
Regular supplementation with 75 mg of resveratrol twice daily has the potential to slow bone loss in the lumbar spine and femoral neck in postmenopausal women without overt osteoporosis.
Limitations
The abstract does not explicitly state any limitations of the study.
Where the published abstract does not list limitations, we say so rather than inventing them. Read the full paper on PubMed before drawing conclusions.
The paper at a glance
| Title | Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial |
|---|---|
| Journal | J Bone Miner Res |
| Year | 2020 |
| PMID | 32564438 ↗ |
| DOI | 10.1002/jbmr.4115 ↗ |
| Topic | Muscle, strength & physical function |
Read the source: PubMed record (authors, abstract, full citation) ↗ · Publisher via doi.org ↗
Where Magellan uses this paper
This citation sits behind the evidence grade on the pages below. Grades are set from the research and are independent of affiliate commissions.
Trans-Resveratrol
In human health, the best-supported effects of resveratrol come from randomized trials and meta-analyses in people with metabolic or cardiovascular risk: pooled trials show modestly better endothelial function (flow-mediated dilation) and small reductions in C-reactive protein, especially at 500 mg/day or more for 10…
Resveratrol (trans-3,5,4'-trihydroxystilbene) is a natural polyphenol produced by grapes, berries…
Research describes the compound or intervention studied. It is not a claim about any specific product.
Molecules & mechanisms in this paper
Each of these is named in the paper’s own words above. Open the monograph for the full mechanism and its other citations.
Cite this page
These citations point at this summary. To cite the original paper with its full author list, use the PubMed record or doi.org.
Magellan Longevity. (2026). Can resveratrol supplementation improve bone health in postmenopausal women? [Plain-English summary of J Bone Miner Res 2020, PMID 32564438, DOI 10.1002/jbmr.4115]. Magellan Longevity. https://magellanlongevity.com/study/x2.html@misc{magellan_x2,
title = {Can resveratrol supplementation improve bone health in postmenopausal women?},
author = {{Magellan Longevity}},
year = {2026},
howpublished = {\url{https://magellanlongevity.com/study/x2.html}},
note = {Plain-English summary of PubMed PMID 32564438; DOI 10.1002/jbmr.4115; J Bone Miner Res 2020. Reviewed by Gabriel Radu, DO},
urldate = {2026-08-11}
}https://magellanlongevity.com/study/x2.htmlRelated studies in the Magellan library
- The Potential of Resveratrol to Act as a Caloric Restriction Mimetic Appears to Be Limited…Advances in Nutrition · 2021 · PMID 33271594
- Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and…Mechanisms of Ageing and Development · 2015 · PMID 25824609
- The Additive Effects of Creatine Supplementation and Exercise Training in an Aging PopulationJ Geriatr Phys Ther · 2020 · PMID 30762623
- Is calcaneal quantitative ultrasound (QUS) associated with 15-year all-cause and…Osteoporos Int · 2022 · PMID 35147712
- The Effect of a Multivitamin and Mineral Supplement on Immune Function in Healthy Older AdultsNutrients · 2020 · PMID 32823974
- Topical delivery of l-ascorbic acid spanlastics for stability enhancement and treatment of UVB…Drug Deliv · 2021 · PMID 33620008
All 28 Magellan summaries on muscle, strength & physical function →
Prefer the interactive version? Open this summary in the Magellan app → · Browse all 314 study summaries →