Does magnesium supplementation affect blood pressure and obesity measures in patients with type 2 diabetes mellitus?
Magnesium Glycinate, a meta-analysis (Biol Trace Elem Res 2020, PMID 32385715) — however, pooling seven RCTs showed a significant reduction in systolic blood pressure (WMD: -5.78 mmHg) and diastolic blood pressure (WMD: -2.50 mmHg). Pooling five RCTs showed that magnesium supplementation did not significantly affect body weight (WMD: -0.01 kg), BMI (WMD: -0.07), or waist circumference (WMD: 0.12).
Source: Biol Trace Elem Res 2020, PMID 32385715 ↗ · Research map · How Magellan grades evidence · evidence confidence: high
Biol Trace Elem Res · 2020 · PMID 32385715 · DOI 10.1007/s12011-020-02157-0
Magnesium supplementation can help lower blood pressure in people with type 2 diabetes, especially with higher doses or longer durations.
The question
Does magnesium supplementation affect blood pressure and obesity measures in patients with type 2 diabetes mellitus?
What they tested
The study aimed to evaluate the effects of magnesium supplementation on blood pressure and obesity measures in type 2 diabetes patients.
How they did it
A meta-analysis of randomized clinical trials (RCTs) was conducted by searching major electronic databases (Web of Science, Cochrane library, PubMed, Scopus) up to October 15, 2019. Outcomes were pooled using a random-effects model and expressed as weighted mean differences (WMD) with 95% confidence intervals (CI). Heterogeneity, sensitivity analysis, and publication bias were also assessed.
What they found
Pooling five RCTs showed that magnesium supplementation did not significantly affect body weight (WMD: -0.01 kg), BMI (WMD: -0.07), or waist circumference (WMD: 0.12). However, pooling seven RCTs showed a significant reduction in systolic blood pressure (WMD: -5.78 mmHg) and diastolic blood pressure (WMD: -2.50 mmHg). Subgroup analysis indicated that magnesium supplementation for more than 12 weeks, at doses higher than 300 mg/day, or in inorganic forms, significantly decreased both systolic and diastolic blood pressure.
| Systolic BP Reduction | -5.78 | |
|---|---|---|
| Diastolic BP Reduction | -2.5 |
Weighted mean differences (WMD) in blood pressure reduction with magnesium supplementation compared to control groups in type 2 diabetes patients.
What it means
Magnesium supplementation has beneficial effects on blood pressure in type 2 diabetes patients, independent of body weight status.
Limitations
The study suggests that further investigations are needed to provide more reliable evidence.
The paper at a glance
| Title | The Effects of Magnesium Supplementation on Blood Pressure Among Type 2 Diabetes Patients: a meta-analysis |
|---|---|
| Journal | Biol Trace Elem Res |
| Year | 2020 |
| PMID | 32385715 ↗ |
| DOI | 10.1007/s12011-020-02157-0 ↗ |
| Topic | Metabolic health, glucose & body composition |
Read the source: PubMed record (authors, abstract, full citation) ↗ · Publisher via doi.org ↗
Where Magellan uses this paper
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Magnesium Glycinate
Pooled analyses of randomized trials indicate oral magnesium lowers blood pressure by a small amount—about 2 mmHg in a 34-trial analysis—with larger reductions in people who are hypertensive, magnesium-deficient, or insulin-resistant, and generally no significant effect in normotensive individuals.
Magnesium is an essential dietary mineral and the second most abundant intracellular cation, serving as…
Research describes the compound or intervention studied. It is not a claim about any specific product.
Molecules & mechanisms in this paper
Each of these is named in the paper’s own words above. Open the monograph for the full mechanism and its other citations.
Cite this page
These citations point at this summary. To cite the original paper with its full author list, use the PubMed record or doi.org.
Magellan Longevity. (2026). Does magnesium supplementation affect blood pressure and obesity measures in patients with type 2 diabetes mellitus? [Plain-English summary of Biol Trace Elem Res 2020, PMID 32385715, DOI 10.1007/s12011-020-02157-0]. Magellan Longevity. https://magellanlongevity.com/study/d32385715.html@misc{magellan_d32385715,
title = {Does magnesium supplementation affect blood pressure and obesity measures in patients with type 2 diabetes mellitus?},
author = {{Magellan Longevity}},
year = {2026},
howpublished = {\url{https://magellanlongevity.com/study/d32385715.html}},
note = {Plain-English summary of PubMed PMID 32385715; DOI 10.1007/s12011-020-02157-0; Biol Trace Elem Res 2020. Reviewed by Gabriel Radu, DO},
urldate = {2026-08-11}
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