What is the effect of genetically predicted glucosamine on male and female lifespan?
D-Glucosamine, a Mendelian randomization analysis in 461,384 individuals (Mendelian Randomization Analysis 2022, PMID 35623867) — a 1-SD increase in genetically predicted glucosamine was associated with higher odds of combined parental age at death (odds ratio, 2.64) and maternal age at death (odds ratio, 1.73). Scope: 461,384 individuals, and the abstract states no limitations.
Source: Mendelian Randomization Analysis 2022, PMID 35623867 ↗ · Research map · How Magellan grades evidence · evidence confidence: medium
Mendelian Randomization Analysis · 2022 · PMID 35623867 · DOI 10.1016/j.clnesp.2022.03.029
Genetically predicted higher glucosamine levels are associated with increased lifespan, particularly for mothers.
The question
What is the effect of genetically predicted glucosamine on male and female lifespan?
What they tested
The study hypothesized that genetically predicted glucosamine would be associated with longevity.
How they did it
A two-sample Mendelian randomization (MR) study was conducted using genetic data from the MRC-IEU consortium for 461,384 individuals. Five genetic variants were identified as instrumental variables for genetically predicted glucosamine. Genetic associations of these variants with parental longevity (combined parental age at death, mother's age at death, father's age at death) were obtained. The inverse-variance weighted method was used to estimate the effect of a 1-standard deviation (SD) increase in genetically predicted glucosamine on parental longevity.
What they found
A 1-SD increase in genetically predicted glucosamine was associated with higher odds of combined parental age at death (odds ratio, 2.64) and maternal age at death (odds ratio, 1.73). No association was found with paternal age at death (odds ratio, 1.32). Sensitivity analyses did not find evidence of pleiotropic effects.
| Combined Parental Age at Death | 2.64 | |
|---|---|---|
| Maternal Age at Death | 1.73 | |
| Paternal Age at Death | 1.32 |
A 1-SD increase in genetically predicted glucosamine was associated with higher odds of combined parental age at death and maternal age at death, but not paternal age at death.
What it means
Lifelong higher levels of glucosamine may increase life expectancy, with positive effects specifically associated with maternal age at death. The sex-specific findings require further investigation.
Limitations
The abstract does not explicitly state limitations beyond suggesting further investigation for the sex-specific finding.
Where the published abstract does not list limitations, we say so rather than inventing them. Read the full paper on PubMed before drawing conclusions.
The paper at a glance
| Title | Genetically predicted glucosamine and longevity: A Mendelian randomization study |
|---|---|
| Journal | Mendelian Randomization Analysis |
| Year | 2022 |
| PMID | 35623867 ↗ |
| DOI | 10.1016/j.clnesp.2022.03.029 ↗ |
| Topic | General aging biology & healthspan |
Read the source: PubMed record (authors, abstract, full citation) ↗ · Publisher via doi.org ↗
Where Magellan uses this paper
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D-Glucosamine
Evidence on glucosamine for aging-related joint health is genuinely mixed: in the landmark 3-year randomized trial of prescription crystalline glucosamine sulfate (n=212), placebo patients lost significant knee joint space (−0.31 mm) while glucosamine patients did not (−0.06 mm), with symptoms improving on…
D-Glucosamine sulfate is a salt of glucosamine, an amino monosaccharide the body synthesizes from…
Research describes the compound or intervention studied. It is not a claim about any specific product.
Molecules & mechanisms in this paper
Each of these is named in the paper’s own words above. Open the monograph for the full mechanism and its other citations.
Cite this page
These citations point at this summary. To cite the original paper with its full author list, use the PubMed record or doi.org.
Magellan Longevity. (2026). What is the effect of genetically predicted glucosamine on male and female lifespan? [Plain-English summary of Mendelian Randomization Analysis 2022, PMID 35623867, DOI 10.1016/j.clnesp.2022.03.029]. Magellan Longevity. https://magellanlongevity.com/study/glu_mr.html@misc{magellan_glu_mr,
title = {What is the effect of genetically predicted glucosamine on male and female lifespan?},
author = {{Magellan Longevity}},
year = {2026},
howpublished = {\url{https://magellanlongevity.com/study/glu_mr.html}},
note = {Plain-English summary of PubMed PMID 35623867; DOI 10.1016/j.clnesp.2022.03.029; Mendelian Randomization Analysis 2022. Reviewed by Gabriel Radu, DO},
urldate = {2026-08-11}
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